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Description

  • GeneName: CBX1; CBX; M31; MOD1; p25beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; HP1 beta.
  • SynName: Homo sapiens chromobox homolog 1 (CBX1), transcript variant 1, mRNA.
  • Clonality: Monoclonal; *Source: Mouse; *Reactivity: Human; *Tested: ELISA (EIA), Western Blot (WB).
  • AppNotes: ELISA: 1/15000 - 1/20000, WB: 1/100-1/2000; *Form: Liquid.
  • Purity: Protein G-Sepharose affinity purified.; *Conc: 50ug/50ul.
  • Perservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4..
  • Immunogen: Recombinant full length of human CBX1.; *Cellular Localization: Nucleus.
  • Pathway: heterochromatin protein family.
  • Storage: Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.
  • FREE-8GB-USBDrive for this item. Item is for research use. NOT for diagnostic/therapeutic procedure..
  • Imported from USA.
*Relevance: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins.; *Accession#: NP_006798.1; NM_006807; *Description: Background: Mouse monoclonal IgG to CBX1.; *NCBI Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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CBX1 Antibody (Antibody)

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