---
product_id: 255644787
title: "Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets"
brand: "doctor's best"
price: "₨51547"
currency: LKR
in_stock: true
reviews_count: 6
category: "Doctor's Best"
url: https://www.desertcart.lk/products/255644787-doctors-best-sam-e-400-mg-vegan-gluten-free-soy
store_origin: LK
region: Sri Lanka
---

# Vegan, Non-GMO purity 400 mg potent SAMe dose Supports mood & cognitive health Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

**Brand:** doctor's best
**Price:** ₨51547
**Availability:** ✅ In Stock

## Summary

> 💥 Elevate your mood, joints, and liver health with every tablet!

## Quick Answers

- **What is this?** Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets by doctor's best
- **How much does it cost?** ₨51547 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.lk](https://www.desertcart.lk/products/255644787-doctors-best-sam-e-400-mg-vegan-gluten-free-soy)

## Best For

- doctor's best enthusiasts

## Why This Product

- Trusted doctor's best brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Mood & Cognitive Boost:** Enhances neurotransmitter synthesis to elevate mood and mental clarity
- • **Joint Comfort & Mobility:** Promotes cartilage protection and supports active lifestyles with improved joint function
- • **Liver Detox & Protection:** Boosts glutathione production to safeguard liver health and detoxification
- • **Clean & Conscious Formula:** Vegan, gluten-free, soy-free, and non-GMO for mindful wellness
- • **Clinically Proven Double Strength:** 400 mg of pharmaceutical-grade SAMe per tablet for maximum efficacy

## Overview

Doctor's Best SAM-e 400 mg delivers a potent, pharmaceutical-grade dose of the active S,S isomer of SAMe, clinically proven to support mood enhancement, cognitive function, joint comfort, and liver detoxification. Crafted with premium Italian SAMe, this vegan, gluten-free, and soy-free formula is designed for professionals seeking scientifically backed, clean supplementation to maintain peak mental and physical performance.

## Description

SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*

Review: لم يعجبني
Review: Sam-e is used in Europe, by prescription, to treat mood disorders, but it's also known for helping with osteoarthritis and joint pain. I started taking it regularly again while doing marathon training. I figured it might help my knees, and if it didn't, it would take the edge off of that lovely mood that sidelined athletes can be in. This made such a difference to my training. I have tried to tell others who complain of knee injuries, but not everyone realizes...this isn't just like another plug for glucosamine or another supplement marketed after the Medicare-supplied walkers commercial. I also noticed I was more anxious when I went without this for a little under a week (had already been anxious and working on it, not as a withdrawal symptom). It's also purported to help liver function and protect DNA. I am not a cell biology expert, but the variety of functions proposed are certainly not implausible from what I do know, as it is a methyl donor.

## Features

- Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
- SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
- SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
- SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
- Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN | B004YLAXOE |
| ASIN  | B004YLAXOE |
| Additives | Amino Acid |
| Age Range Description | Adult |
| Allergen Information | Gluten Free, Soy Free |
| Best Sellers Rank | #38,337 in Health ( See Top 100 in Health ) #1,087 in Multiple Vitamin-Mineral Combination Supplements |
| Brand | Doctor's Best |
| Customer Reviews | 4.6 4.6 out of 5 stars (3,340) |
| Customer reviews | 4.6 4.6 out of 5 stars (3,340) |
| Date First Available | 9 August 2012 |
| Format | Tablet |
| Is Discontinued By Manufacturer  | No |
| Item model number  | DRB-00252 |
| Manufacturer  | Doctor's Best |
| Product Dimensions  | 8.26 x 5.08 x 15.57 cm; 90.72 g |
| Serving Recommendation | 1 tablet |
| Units | 60 Count |
| Weight | 10 Grams |

## Product Details

- **Brand:** Doctor's Best
- **Diet type:** Vegan
- **Flavour:** Unflavored
- **Item dimensions L x W x H:** 8.3 x 5.1 x 15.6 centimeters
- **Item form:** Tablet
- **Item weight:** 0.2 Pounds
- **Primary supplement type:** Amino Acids
- **Product benefits:** Detoxing
- **Special ingredients:** Amino Acid
- **Unit count:** 60 Count

## Images

![Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg)

## Questions & Answers

**Q: Is each tablet packaged in foil?**
A: The tablets are in a ten count foil blister pack. Each pill has it's own sealed compartment. I am an RN and this is like medical grade packaging. Safe.

**Q: Could this cause you to feel warm or hot and sometimes dizziness?**
A: SAM-e, especially when combined with other medications, has a potential to contribute to Seratonin Syndrome, which can cause temperature disregulation and dizziness. This is a supplement that effects the function of your brain and neural pathways. Please make sure you use it as directed and preferrably under the care of someone who is knowledgeable on the subject if you have not done your own research. If any adverse reactions occur, stop taking the supplement and please talk to your doctor about it. There is the potential for very bad reactions if Seratonin builds up too much. 

Every person's brain is unique and will react in different ways. Nothing involved in brain support supplements are a one-size-fits-all.

**Q: how long does it take to start working**
A: I have taken SAM-e for 15 years very successfully. It has never failed to work for me, unlike Rx antidepressants and other supplements (like St John's Wort). In the last year I have increased from 1 400 mg pill daily to 2. I'm in my 60s and i just seem to feel better with more. (It is also anti-aging because it helps correct the mistakes that accumulate in our DNA). In my experience SAM-e works very quickly. If I need a boost, I take an extra dose and I feel better within 1-2 hours. You can take up to 1600 mg in a day (four 400 mg pills) with no problem. If I know I'm going to have a stressful day I will head off problems by taking 2 upon awakening, and then 1-2 more later in the day, when I can be sure of an empty stomach. It's important to take SAM-e at least 30 minutes before food, or 2 hours after, for best absorption.

**Q: How do these compare to nature made? That's my usual.**
A: For me, I like Nature Made so much better. Nature Made worked for my husband and I. We switched to these in an effort to save money and within two weeks of the switch we both started hurting again. Also these came with several of the bubbles punctured and the pills were different colors, within the pack. If you read some of the recent reviews, you’ll see others had some of the same issues and far as punctured blister packs and color changes within the box. We switched back to Nature Made, which was the brand our Orthapedic doctor had recommended.

## Customer Reviews

### ⭐ Review
*by ش***ي on 16 December 2023*

لم يعجبني

### ⭐⭐⭐⭐⭐ Review
*by K***. on 24 February 2013*

Sam-e is used in Europe, by prescription, to treat mood disorders, but it's also known for helping with osteoarthritis and joint pain. I started taking it regularly again while doing marathon training. I figured it might help my knees, and if it didn't, it would take the edge off of that lovely mood that sidelined athletes can be in. This made such a difference to my training. I have tried to tell others who complain of knee injuries, but not everyone realizes...this isn't just like another plug for glucosamine or another supplement marketed after the Medicare-supplied walkers commercial. I also noticed I was more anxious when I went without this for a little under a week (had already been anxious and working on it, not as a withdrawal symptom). It's also purported to help liver function and protect DNA. I am not a cell biology expert, but the variety of functions proposed are certainly not implausible from what I do know, as it is a methyl donor.

### ⭐⭐⭐⭐⭐ Review
*by A***R on 23 August 2025*

I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.

## Frequently Bought Together

- Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets
- Doctor's Best SAM-e Mood & Joint Support & Liver Health (Pharmaceutical Grade/Non-GMO/Gluten Free/Vegetarian), Tablet, 60 Count (Pack of 1)
- Doctors BEST High Absorption Magnesium Lysinate Glycinate 100% Chelated, Muscle Relaxation & Sleep Support, Non-GMO, Gluten Free, Soy Free, Vegan, 100% Chelated 240 Tablets

---

## Why Shop on Desertcart?

- 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016
- 🌍 **Shop Globally** — Access 737+ million products across 21 categories
- 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price
- 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members)
- 🔒 **Secure Payments** — Trusted payment options with buyer protection
- ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews

**Shop now:** [https://www.desertcart.lk/products/255644787-doctors-best-sam-e-400-mg-vegan-gluten-free-soy](https://www.desertcart.lk/products/255644787-doctors-best-sam-e-400-mg-vegan-gluten-free-soy)

---

*Product available on Desertcart Sri Lanka*
*Store origin: LK*
*Last updated: 2026-03-10*