Pure Encapsulations Adenosyl/Hydroxy B12, 90 Capsules | High-Potency B Vitamin, for Energy Metabolism and Neurological Support*, Brain Support Supplement*, Vegan and Gluten-Free

I am already taking a B vitamins pill. And my B-12 blood levels is already decent. But my doctor likes B-12 levels pretty high. I see some people take this because they have issues with more common forms of B-12. I don’t. I’m already getting decent blood levels. But I figured that if my doctor likes the levels even higher, it might make sense to add some additional forms of B-12. Therefore, I picked this product. And of course, Pure Encapsulations is a good brand with no fillers or stearates. I see some people with corn allergies have a problem with this product. I don’t, so it’s fine for me. The capsule is nice and small, easy to swallow. And my blood B-12 levels are now actually considered elevated, higher than normal. So, I know it is working. The first time I took one, when I peed an hour later, it was extra dark. I don’t think it meant anything, other than probably I’m getting more B-12 than I can use.

This is much better than methylated b complex vitamins for my homozygous MTHFR, MTRR, and MTR methylation detox cycle gene defects, specifically because I have a heterozygous COMT gene mutation. It allows my body to decide how much B12 it wants to convert into active forms and where. Methylated vitamins don't allow this, and it's why I also take folinic acid (not to be confused with folic acid). I also have a homozygous folate transporter gene mutation, meaning not enough is getting to my brain. Methylated vitamins are also only one final form of these vitamins. With multiple gene mutations, and a strict diet from MCAS and more, I have to take this stuff. It's made a HUGE improvement on my mental and physical health. NOTE: Info is not meant to diagnose or treat others. I'm not a healthcare professional. Thank you!

My son doesn't seem to translate B12 pulls into serum B12 levels but this brought him from the serum 200s into the 500s. Small pills, easy to take, and effective!

Important addition for health – quality product

Have you tried taking B12 for the energy boost you've heard so much about - maybe even the Methylcobalamin form that we all hear so much about - but you're just not feeling it? Or... do you have the MTHFR gene mutation, but are experiencing mood and/or anxiety problems when taking methylfolate? This form of B12 should help. I take methylfolate in divided doses usually twice a day, for a total of about 3,200 mg daily. When I first started taking methylfolate, I experienced some pretty bad mood issues - from anxiety to outright anger. The feelings of anger were the worst for me - there was no reasonable explanation for why I was experiencing this emotion. As it turned out, it was the methylfolate causing these mood and anxiety issues. So, I hit the books again, and discovered that taking extended release niacin should help. I started taking 500mg of extended release niacin each morning along with my first dose of methylfolate; and I did have some improvement, but not enough. This mood problem caused me to stop taking the methylfolate. As I knew I should be taking the methylfolate, I continued to study and look into the problem of the methylfolate causing the anxiety/anger issues. I discovered that the Adenosyl/Hydroxy B12 is not metabolized as fast as Methylcobalamin B12. Since the levels of this B12 stays available longer for metabolism, and is needed to help methylfolate, the theory is that it should help alleviate those pesky mood symptoms. Now, B vitamins should always be taken in a complete complex, or all B vitamin forms should be taken together, as they need each other for any one to perform optimally in the body. Also, B vitamins should be taken in divided doses at least twice a day. But back to the question of did this form of B12 help? Yes! It did help me tremendously. Not only did the anxiety and anger symptoms of taking the methylfolate subside - but FINALLY I was experiencing the energy boost that B12 is supposed to help with. Now, the energy I experience is not like gulping down a triple espresso latte; it's more like "Hey, I feel good today. Let's get that spring cleaning done." My mood has improved overall with a feeling that I have the physical energy to do those things I want to do. It feels good again to get out a move my body and use those muscles. I sure hope others find this supplement at useful as I have. By the way - this is a TINY capsule and very easy to take.

I got test results that my b-12 serum test was super high which was odd because I was only taking a b-complex with methylcobalamin. All my family also have high b-12 in blood serum so Im wondering if its a genetic issue. I did a MMA (The methylmalonic acid test to see if my body is absorbing the B-12 or if its not processing due to a malsporption issue. Test came back high - basically meaning that Im not absorbing the methylcobalamin. So I am trying these forms out to see if they help me out. So far so good will update but I dont have any new test results yet. If you are deficient in b-12 for a long time there are irreversible effects like dementia so I really want to make sure my b-12 is right.

This b12 formula was recommended to me by my doctor for low energy. She recommended this specific brand because of her pervious experience with other patients. My second dose proved to be very effective for my energy level , in fact I think it even improves my mood, my focus and my brain fog. I am sure it is effective because I have not done anything else different. .

Great dose amount, easy to swallow capsules but also easy to open if you’re putting it in a beverage to drink My special needs kiddo has this in her coconut milk daily and she doesn’t mind the taste or color at all.