Doctor's Best SAM-e Supplement for Men & Women, 60 Enteric Coated Tablets

SAMe was a recommended supplement in Dr. Daniel Amen's book, "Making a Good Brain Great". There is a section in the brain, called the Deep Limbic System (DLS) and when it is not functioning right (excessive activity in this part of the brain), these problems can occur: depression, sadness, focusing on the negative, irritability, low motivation and energy, negativity, social disconnection/isolation, low self-esteem, crying spells, feelings of hopelessness or worthlessness. I was experiencing all of these. Some days I would be fine and other days I felt like I was losing my mind. I had absolutely nothing to be depressed/sad about and the littlest things would bother me and/or make me upset. I was also very irritable. It was getting out of control and it was really affecting my life and my relationship with my boyfriend. I am not too keen on taking any type of pill, which is why I avoided going to see a doctor. I knew he/she would only prescribe me anti-depressants of some sort, which are not only expensive, but also have many negative side effects. This is when I decided to give SAMe a try - and it has changed my life like I never thought possible. It improved my mood and my motivation. I am not nearly as negative and irritable as I was before and I feel really good about my life and in general. For the women out there, I also noticed an improvement in my PMS symptoms. A few things to take note of: -Check with your doctor first before taking. I didn't, but you really should. -Start off with a lower dose. I first started with 400mg and after a few days I started getting anxiety and also a headache shortly after taking. The better dose for me is 200mg, but everyone is different. -Take a vitamin B supplement with SAMe. More specifically, B12, B6 and Folate. This helps with absorbency. -DO NOT take if you have bipolar disorder or are taking other anti-depressants. SAMe is best taken on an empty stomach. Wait 30 minutes or so before eating. I take mine in the morning, along with a vitamin B complex and it has worked out very well. Also be sure to give it time to work. I saw the most improvement after 2 weeks of daily usage. Hope this helps :-)

I’ve suffered from depression since I was 11. I am now 34. I was prescribed an Antidepressant in my twenties and I didn’t like the effect it had on me. I’ve always fought this on my own and tried different methods but I could not stay consistent due to my frequent breakdowns and mood changes. My coworker show this to me and I went ahead and gave it a try and I absolutely love it. I can’t explain the change in my moods, it’s like I’m more clear and can enjoy being happy longer with simple things. My thoughts aren’t spiraling out of control..I can control my emotions more . I am able to get things done instead of finding a way to lay in bed or distant myself. It’s truly amazing. I’m telling more people about this. It truly has made a difference in my life and others. The only down side to this is it does cause diarrhea lol but honestly I’d take diarrhea over depression any day. I’m now just looking into a probiotic lol ***also it’s not just the supplement that going to change you, basically it has stabilized me to where I can do things to better myself and strengthen myself mentally. If you are taking this for depression you can’t just depend on a pill you have to go out and take action. Utilize it to tackle your challenges goals and new positive habits. I hope It does good to you how it has done for me. <3

I never leave reviews on anything.. I wish I had found out about Sam-E years ago!!! I have had SAD, and moderate depression with anxiety for years! I have been on Prozac, Effexor, Wellbutrin, Zoloft, Provigil, Xanax, Valium.. just about everything over a 25+ year span. Those almost all worked (eventually) But I would go off of them in hopes "I didn't need them any more" just to be trapped in a big cycle, funding Big Pharma.. My father died last year and I had been on an all time low for 6 months. Hardly got out of bed, didn't want to leave the house, much less go see the Dr for more pills I didn't want to take again.. I was really bad, extreme fatigue, the smallest task was enormous and exhausting. I spent roughly 75% of my day In bed! I swear, serious depression and anxiety for not getting anything done.. I'm taking a break from cleaning out my pantries and mopping right now! I feel fantastic! I have energy, I feel upbeat, positive.. it's truelly amazing! The only reason I tried this is because of the raving reviews, I've since added vitamins, B12 and lithium orotate. If something truelly works well for us as human beings it is our responsibility to spread the word... If you are on the fence, try this! I'm so glad I did!! I take 2 200 mg a day.. ~one happy camper

This stuff can work great, but keep in mind everyone is different and not everyone should be taking SAMe. It was so strong for me that I was only taking 50mg a day. I had to use a pill cutter and tightly wrap each piece in plastic wrap and use the 4 pieces within 4 days otherwise it broke down too fast. It gets glossy looking or gooey when bad. One thing people don't understand about SAMe is that it will increase your estrogen or play on your estrogen receptors. I think that is part of the reason it can work on depression, because increased estrogen also increases your brain chemicals serotonin and dopamine. But here's the tricky part: It only increases your estrogen by increasing your methylation process. I am so sensitive that I can tell small changes that happen to my body. I have had a hysterectomy and am on hormone pellets estradiol and testosterone. In the beginning of my pellets they come on strong and SAMe causes "too much" of the already too much hormones. At the end of the 3 month pellet dosing I am feeling low in hormones and the SAMe can sometimes help get me through by increasing my estrogens. The only thing is that flip flopping your neurotransmitters around by stopping and starting can be more of a shock than it's worth. I have felt euforia and I have felt anxiety and paranoia while on SAMe. I am one of those people who have tons of homozygous methylation dna problems and the bad COMT estrogen metabolism snp's. Just be careful and pay attention to how you are feeling. If your boobs swell up and you get anxiety while on it, that probably means you are overmethylating and getting too much estrogen in an already estrogen dominant body. Maybe you need Methyl folate and Methyl B12 and progesterone instead.

Love it. And it helps tremendously with my autism, and my lyme disease. My only hang up and it's not that important. Is the last two orders that I've made have come in the old boxes instead of the new ones. I don't know if the new boxes or a temporary branding thing and they realize they weren't selling as much or what, or maybe they have old boxes left behind and they're just using them while they still can but it's all the same product with all the same ingredients so I'm not concerned

I purchased this item after doing a lot of research into medicinal for depression. I have been suffering from mild to moderate depression, which runs in my family. At times I would even categorize my depression as fairly severe with all the traditional tell-tale signs...lack of desire for things that I usually love, very low motivation, a "dark cloud" ominous sense of dread, general sadness, crying for no reason. I had to fight to get out of bed. I read that SAM-e has a roll in how your body makes serotonin, so I purchased this and have been taking it on the dosage guidelines listed in the Mayo Clinic (http://www.mayoclinic.org/drugs-supplements/same/dosing/hrb-20059935) and am now finishing my "1,200 milligrams daily for nine days" part of the cycle. I noticed a difference in less than a week. It has been a savior to me. I haven't felt that detached feeling that I was encircling my life. The best way to describe it is that I have "access" to a range of emotions now and I don't default directly to gloomy. I have notice, as other have said, a problem with moderate insomnia (it seems to exacerbate an already existing issue for several commentators). I have more energy, more focus, generally happier, peaceful. I will continue taking this product and recommend it to others with similar issues....Doctor's Best individually wraps their product which apparently is imperative to really getting the most out of SAM-e. Hope it works well for you too!

I use Sam-E for PMDD. I have used prescription anti- depressants which have worked okay in the past but eventually stopped working. Searching for an alternative non-addictive form of medicine, I decided to give SAM-E a try. Over the past couple of years I have tried several brands. Although a couple others have worked, the prices for those brands were considerably more. Doctor's Best Sam- E works just as well and doesn't hurt your pocket nearly as much. Sam- E may not work for everyone, but before giving up, I suggest you play with the dosage. For me, one tablet was useless. I settled with 400mg as a daily dose and then up it to approximately 600mg for approximately one week a month. I have been regularly using Doctor's Best for about a year and am very happy with it. I do combine it with a Vitamin B complex which I understand assists in the effectiveness of the Sam-E. Be sure to take it first thing in the morning, because it can cause restlessness and insomnia for some if you take it later in the day.

I have ADD for which I treat with a prescribed drug. I tried to quit taking my meds out of concerns for long-term side effects and tried this brand of SAMe in hopes that it would help with the lethargy experienced when I stopped taking my prescription. I did notice a slight increase in physical energy but nothing in the way improved cognition. I thought this would help with my ability to concentrate because it supposedly helps in creating the neurotransmitter dopamine. Perhaps the increased energy boost was the result of other supplements such as the active form of B-12 (methylcobalamin), n-acetyl-l-choline, Magnesium Glycinate(Chelated), CoQ10 (Ubiquinol) and Zinc Picolinate. Yes, I went supplement crazy in desparation to get of my ADD drug. If the energy boost I felt was the result of this product, it was temporary. I became anxious after taking 1200mg a day for about a week. I reduced the dosage and began to feel extremely tired and sleepy thereafter. I concluded that I had received all the benefits of this product possible and simply stopped taking it. I think I would have just been fine to stick with the Rite-Aid version of the supplement, its cheaper and probably every bit as good as this brand. I'm not bitter, though. I had to take the gamble to see if I could replace my meds. I think this is a good brand, just overpriced for the minor benefits I "think" I noticed. If you have ADD, you will not regain your ability to concentrate or the motivation you experience on prescription meds. On a side note, the other supplements I mentioned above allowed me to sit still for about 30 minutes at a time to perform tasks that anyone can do in their sleep! I grew weary of the lethargy and went back to my doctor for more meds. Nothing works like my prescription drug.

After only a couple of days of taking, these make me feel very ill. They make me go very pale in colour (to the point people are telling me I look pale), and not so Much a headache, but a heavy feeling down one side of my head. I wanted them for Joint support but I will pass…